House Masters: Jim and Doreen Hogle


Photo by Martha Stewart

James Hogle

James Hogle is the Edward S. Harkness Professor of Biological Chemistry and Molecular Pharmacology at the Medical School, professor of biophysics in the Faculty of Arts and Sciences, and chair of the Committee on Higher Degrees in Biophysics. This is his third year as Master of Dudley House. Hogle has been on the Harvard faculty since 1991. Serving as co-master is his wife Doreen, an intellectual property attorney in Concord, Massachusetts.

Margot Gill, administrative dean of GSAS, headed the search committee for the master of Dudley House. "Jim is a respected scientist and a dedicated teacher and advisor who has worked closely with graduate students in his biophysics lab," Gill said. "He brings to the graduate student center intellectual vigor, a strong sense of community, and a wonderful sense of humor."

Hogle is best known for his work on the structure and function of viruses and viral proteins. In 2000, at his X-ray crystallography lab at the Medical School, Hogle produced the first 3-D structure - essentially, snapshots - of the poliovirus in the moments after it attaches to and enters a host cell. Hogle has used his insights into polio to study other viruses such as those leading to heart disease, encephalitis, and diabetes.

Hogle has published in Structure,The Journal of Virology, The Journal of Molecular Biology, and other scholarly journals. His awards include the National Institutes of Health's Wallace P. Rowe Award for Excellence in Virology in 1991, and the American Association for the Advancement of Science Newcomb Cleveland Prize in 1985. Hogle is a member of several professional societies, including the American Society for Virology, and serves on the editorial boards of a number of scholarly publications. He earned a bachelor of science degree from the University of Minnesota in 1972 and the PhD in biochemistry from the University of Wisconsin at Madison in 1978. Hogle was a postdoctoral fellow at Harvard from 1978 to 1982.

One issue Hogle and GSAS administrators have been working on is to bridge the gap between graduate students working at the Medical School campus in Boston and Dudley House. "I have been a big proponent of blurring some of the distinctions between the Medical School and the Cambridge campuses in terms of graduate studies," Hogle said. "But there is a huge 'inertial barrier' -- the M2 shuttle! I think that Dudley House can do a great deal to decrease barriers between the campuses and increase the sense of community among all GSAS students and faculty. Given the separation between the campuses, it is especially important that students in the Division of Medical Sciences become more aware of the tremendous intellectual resource and support structure Dudley House provides. Having a master who is located in the Medical School, but who also has roots in Cambridge, helps with these goals."

Doreen Hogle

Doreen M. Hogle, the Dudley House Co-Master, is very enthusiastic about her responsibilities and opportunities here at Dudley. She joins Jim Hogle in enjoying having gotten to know the Dudley students and staff and participating in many of the wonderful House activities organized by the Dudley Fellows. Please introduce yourself to her when you meet her in the House.

Doreen M. Hogle received a B.S. from Marquette University, with a major in Medical Technology and a minor in Chemistry and is a graduate of the University of San Diego School of Law. She is registered to practice before the United States Patent and Trademark Office and has extensive experience in biotechnology and chemistry. Ms. Hogle is also a member of the Bars of the Commonwealth of Massachusetts, the State of California, the United States District Court for the District of Massachusetts, the Southern District of California, and the United States Court of Appeal for the Federal Circuit. She is also a member of the American Bar Association, the Licensing Executive Society, and is the Secretary and Treasurer of the Boston Patent Law Association and co-chair of the Biotechnology Committee. Ms. Hogle has also authored "Copyright for Innovative Biotechnological Research: An Attractive Alternative to Patent or Trade Secret Protection", 5 High Tech. L. J. 75 (1990).

Ms. Hogle has co-authored six scientific publications and is a co-inventor on a U.S. Patent covering an immunodiagnostic assay. Ms. Hogle was also a marketing specialist for a medical instrumentation/immunodiagnostic company.

Doreen Hogle is a partner in the intellectual property law firm Hamilton, Brook Smith and Reynolds, located in Concord, MA. She has been with them for 11 years. They have about 60 patent attorneys/agents/technical specialists practicing in all areas of intellectual property prosecution and litigation.

Ms. Hogle's practice is concentrated in the areas of genomics, bioinformatics, chemistry, immunology, and structural biology. She has extensive experience in advising clients in all matters of patent portfolio management, as well as providing infringement, validity, and freedom-to-operate opinions. She also has experience in licensing and due diligence studies. Her clients include academic institutions, hospitals and biotechnology/pharmaceutical companies of all sizes.