Jon C Clardy
Department of Biological Chemistry & Molecular Pharmacology
tel: (617) 432-2845; fax: (617) 432-6424
The laboratory concentrates on two broad aims: the discovery of new biologically active small molecules and the role of small molecules in the flow of biological information. To discover small molecules, we use approaches ranging from chemical ecology to genome sequencing. These approaches have led to the discovery of new biologically active small molecules, new biosynthetic pathways, and new signaling systems.
The projects on small molecule signaling systems include projects on the culturability of bacteria, the development of nematodes and choanoflagellates, and how pathogens influence their hosts. We are also developing small molecule screens for malaria and exploring novel biochemical pathways of P. falciparum.
The laboratory employs a variety of methods including small molecule chemistry, protein crystallography, biochemical analysis, and high-throughput screening.
Fischbach, M.A., Walsh, C.T., and Clardy, J. (2008). The evolution of gene collectives. Proc. Natl. Acad. Sci. USA 105: 4601-4608.
Fischbach, M.A., and Clardy, J. (2007). One pathway, many products. Nature Chem. Biol. 3: 353-355.
Lautenschlager, C., Leal, W.S., and Clardy, J. (2007). Bombyx mori pheromone-binding protein binding nonpheromone ligands: implications for pheromone recognition. Structure 15: 1148-1154.
Butcher, R.A., Fujita, M., Schroeder, F.C., and Clardy, J. (2007). Small-molecule pheromones that control dauer development in Caenorhabditis elegans. Nature Chem. Biol. 3: 421-422.
Butcher, R.A., Schroeder, F.C., Fischbach, M.A., Straight, P., Kolter, R., Walsh, C.T., and Clardy, J. (2007). The indentification of bacillaene, the product of the PksX megacomplex in Bacillus subtilis. Proc. Natl. Acad. Sci USA 104: 1506-1509.
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