Gregory L. Verdine
Department of Stem Cell and Regenerative Biology
The research interests of the Verdine lab lie in the emerging area of chemical biology. We study biologic processes underlying growth and proliferation of human cancer cells, control of gene expression, and preservation of genomic integrity. Our research has led to the invention of new and powerful approaches for the discovery of unconventional bioactive ligands termed "synthetic biologics" that have proven effective at addressing therapeutic targets previously considered "undruggable." Verdine and coworkers have elucidated the mechanism by which DNA methyltransferases catalyze epigenetic modification of the genome, as well as the structural basis for sequence specific DNA recognition by NF- κB and NFAT, master regulators of acute phase and immune responses and organ development. Our work has illuminated the biochemical and structural basis for enzymatic recognition and removal of mutagenic damage in DNA.
Huang, H.; Chopra, R.; Verdine, G. L.; Harrison, S. C. "Structure of a Covalently Trapped Catalytic Complex of HIV-1 Reverse Transcriptase: Implications for Drug Resistance," Science (1998), 282:1669-1675.
Zhou, P.; Sun, L. J.; Dštsch, V.; Wagner, G.; Verdine, G. L. "Solution Structure of the Core NFATC1/DNA Complex," Cell (1998), 92:687-696.
Haushalter, K. A.; Stukenberg, P. T.; Kirschner, M. W.; Verdine, G. L. "Identification of a New Uracil-DNA Glycosylase Family by Expression Cloning Using Synthetic Inhibitors," Current Biology (1999), 9:174-185.
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