George M. Church
Department of Genetics
tel: (617) 432-1278; fax: (617) 432-7266
Our research focuses on new technologies for DNA, RNA, protein measurement and synthesis and modeling of biomedical & ecological systems – in particular, personal genomics and biofuels. We have developed next-generation sequencing methods to analyze the output of combinatorial selections as well as comprehensive gene-environment-trait data for affordable personalized medicine. We reprogram human skin-derived pluripotent skin cells to connect cis-regulatory motif variants in populations to allele-specific and cell-type-specific RNA measures and further to causal effects on cell and larger-scale morphologies. We are developing tools for connecting functional microbiomics with (VDJ-ome) immune responses.
Selected Publications (others are on our web page):
Dantas, G., Sommer, M.O., Oluwasegun, R.D., and Church, G.M. (2008). Bacteria Subsisting on Antibiotics. Science 320(5872): 100-3.
Bang, D., and Church, G.M. (2008). Gene Synthesis by Circular Assembly Amplification. Nature Methods 5(1): 37-9.
Kim, J.B., Porreca, G.J., Gorham, J.M., Church, G.M., Seidman, C.E., and Seidman, J.G. (2007). Polony Multiplex Analysis of Gene Expression (PMAGE) in a Mouse Model of Hypertrophic Cardiomyopathy. Science 316(5830): 1481-4.
Bakal, C., Aach, J., Church, G.M., and Perrimon, N. (2007) Defining the Components Of Local Signaling Networks That Regulate Cell Morphology Using Quantitative Morphological Signatures. Science 316(5832): 1753-6.
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