Collin M. Stultz

Department of Electrical Engineering and Computer Science
& Harvard-MIT Division of Health Science and Technology
Massachusetts Institute of Technology
Building 36 -Room 796
77 Massachusetts Avenue, Cambridge, MA 02139

tel: (617) 253-4961

Research Interests

We are interested in conformational changes in macromolecules and the effect of structural transitions on common human diseases. Since conformational transitions in biomolecules are typically difficult to observe experimentally, we use novel methods to gain insights into the role that molecular structure plays in the progression of human disease. We employ an interdisciplinary approach that utilizes techniques drawn from computational chemistry, signal processing, and basic biochemistry.

Selected Publications:

Collin M. Stultz. (2002). Localized unfolding of collagen explains collagenase cleavage near imino-poor sites. J. Mol. Biol. 319:997-1003.

Collin M. Stultz, Andrew D. Levin, Elazer R. Edelman. (2002). Phosphorylation induced conformational changes in a MAP-kinase substrate: Implications for tyrosine hydroxylase activation. J. Mol. Biol. 277:47653-47661.

Collin M. Stultz and Elazer R. Edelman. (2003). A structural model that explains the effects of hyperglycemia on collagenolysis. Biophysical Journal. 85:2198-2204.

Collin M. Stultz, An Assessment of Potential of Mean Force Calculations with Implicit Solvent Models. J. Chem. Phys. In Press.

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